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to triage and cluster sequence data, assign species labels, build large guide trees, identify mis-tracked samples, and search genomic databases. Potential applications include any problem where an approximate, global distance is acceptable, e.g. This has important applications for large-scale genomic data management and emerging long-read, single-molecule sequencing technologies. Thus, sketches comprising just a few hundred values can be used to approximate the similarity of arbitrarily large datasets. Importantly, the error of this computation depends only on the size of the sketch and is independent of the genome size.
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Using only the sketches, which can be thousands of times smaller, the similarity of the original sequences can be rapidly estimated with bounded error. To address this, we consider the general problem of computing an approximate distance between two sequences and describe Mash, a general-purpose toolkit that utilizes the MinHash technique to reduce large sequences (or sequence sets) to compressed sketch representations. New methods are needed that can manage and help organize this scale of data. Of course, there are tons of other events that will take place before those momentous occasions, and Cocoa, Rize, Syaro, and Chiya have plenty of adventures of their own to look forward to.When BLAST was first published in 1990, there were less than 50 million bases of nucleotide sequence in the public archives now a single sequencing instrument can produce over 1 trillion bases per run. It seems like only yesterday that she arrived at the unusual restaurant/boarding house and made it her goal to become an "older sister" to the owner's young daughter, Chino, and now Chino and her friends Megumi and Maya have nearly finished middle school and are trying to decide what high schools to attend!
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